國家衛生研究院 NHRI:Item 3990099045/3384

NHRI > Institute of Biotechnology and Pharmaceutical Research > Kak-Shan Shia > Periodical Articles > Item 3990099045/3384

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3384

Title:	Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists
Authors:	Chu, CM;Hung, MS;Hsieh, MT;Kuo, CW;Suja, TD;Song, JS;Chiu, HH;Chao, YS;Shia, KS
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	Based on the bioisosteric replacement of the pyrazole C3-carboxamide of rimonabant with a 5-alkyl oxadiazole ring, a novel class of oxadiazole derivatives with promising biological activity towards CB1 receptors was discovered. Among them, compounds with an alkyl linker containing a strong electron-withdrawing group (e.g., CF3) and a sterically favorable bulky group (e.g., t-butyl) exhibited excellent CB1 antagonism and selectivity, and thus might serve as potential candidates for further development as anti-obesity agents. 穢 2008 The Royal Society of Chemistry.
Date:	2008-09-21
Relation:	Organic and Biomolecular Chemistry. 2008 Sep 21;6(18):3399-3407.
Link to:	http://dx.doi.org/10.1039/b807648k
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1477-0520&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000259407800023
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=52649148140
Appears in Collections:	[Kak-Shan Shia] Periodical Articles [Yu-Sheng Chao(2002-2013)] Periodical Articles [Ming-Shiu Hung] Periodical Articles

Files in This Item:

File	Description	Size	Format
SCP52649148140.pdf		202Kb	Adobe PDF	922	View/Open