國家衛生研究院 NHRI:Item 3990099045/3388
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    題名: Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma
    其他題名: Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor γ
    作者: Lee, YZ;Yang, CW;Kang, IJ;Wu, SH;Chao, YS;Chern, JH;Lee, SJ
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: We identified a series of 2-phenyl-ethenesulfonic acid phenyl ester analogues as novel dual-function agents that suppressed nitric oxide production in lipopolysaccharide/interferon γ-stimulated RAW264.7 cells and activated peroxisome proliferator-activated receptor γ (PPARγ) in a cell-based transactivation assay. Western blot analysis demonstrated that these compounds inhibit the expression of inducible nitric oxide synthase protein, and scintillation proximity assay validated their ability to bind to PPARγ. Our studies provide the basis for developing these dual-function agents for anti-inflammation and anti-atherosclerosis therapy. ? 2008 Elsevier Ltd. All rights reserved.
    日期: 2008-10-15
    關聯: Bioorganic and Medicinal Chemistry Letters. 2008 Oct 15;18(20):5676-5679.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2008.08.107
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000259972800077
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=53549113033
    顯示於類別:[李秀珠] 期刊論文
    [陳志豪] 期刊論文
    [趙宇生(2002-2013)] 期刊論文

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