國家衛生研究院 NHRI:Item 3990099045/3400
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    題名: Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients
    作者: Su, WP;Wen, CC;Hsiung, CA;Su, IJ;Cheng, AL;Chang, MC;Tsao, CJ;Kao, WY;Uen, WC;Hsu, CH;Lu, YS;Tien, HF;Chao, TY;Chen, LT;Whang-Peng, J;Chen, PJ
    貢獻者: National Institute of Cancer Research;Division of Clinical Research;Division of Biostatistics and Bioinformatics
    摘要: Aim: To investigate the long-term consequences of chemotherapy-related HBV reactivation in patients with lymphoma. Methods: This study was based on the database of published prospective study evaluating HBV reactivation in HBV lymphoma patients during chemotherapy. Deteriorated liver reserve (DLR) was defined as development of either one of the following conditions during follow-up: (1) newly onset parenchyma liver disease, splenomegaly or ascites without evidence of lymphoma involvement; (2) decrease of the ratio (albumin/globulin ratio) to less than 0.8 or increase of the ratio of INR of prothrombin time to larger than 1.2 without evidence of malnutrition or infection. Liver cirrhosis was diagnosed by imaging studies. Results: A total of 49 patients were included. The median follow-up was 6.2 years (range, 3.9-8.1 years). There were 31 patients with and 18 patients without HBV reactivation. Although there was no difference of overall survival (OS) and chemotherapy response rate between the two groups, DLR developed more frequently in patients with HBV reactivation (48.4% vs 16.7%; P = 0.0342). Among the HBV reactivators, HBV genotype C was associated with a higher risk of developing DLR (P = 0.0768) and liver cirrhosis (P = 0.003). Four of five patients with sustained high titer of HBV DNA and two of three patients with multiple HBV reactivation developed DLR. Further, patients with a sustained high titer of HBV DNA had the shortest OS among the HBV reactivators (P = 0.0000). No patients in the non-HBV reactivation group developed hepatic failure or liver cirrhosis. Conclusion: Chemotherapy-related HBV reactivation is associated with the long-term effect of deterioration of hepatic function. ? 2005 The WJG Press and Elsevier Inc. All rights reserved.
    日期: 2005-09-14
    關聯: World Journal of Gastroenterology. 2005 Sep 14;11(34):5283-5288.
    Link to: http://www.wjgnet.com/1007-9327/abstract_en.asp?f=5283&v=11
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1007-9327&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000208100200005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=26244431734
    顯示於類別:[彭汪嘉康(1996-2007)] 期刊論文
    [蘇益仁(2002-2015)] 期刊論文
    [熊昭] 期刊論文
    [陳立宗] 期刊論文

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