國家衛生研究院 NHRI:Item 3990099045/3488
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    题名: Proteomic analysis of proteins associated with tt-DDE induced toxicity in BEAS-2B cells
    作者: Lin, PP;Yang, MH;Liao, PC;Wu, HY;Chang, LW;Tsai, HT;Tyan, YC
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Trans, trans-2,4-decadienal (tt-DDE), a specific type of dienaldehyde, is abundant in heated oils or cooking oil fumes. Ingestion of heated oils and exposure to cooking oil fumes has been suggested to have a great health impact in a variety of organs, including the lungs. Previous studies have demonstrated that acute exposures to high doses of tt-DDE have induced oxidative stress, genotoxicity, and cytotoxicity in human lung cells. The objective in utilizing proteomic techniques of this study was to identify protein biomarkers associated with tt-DDE-induced oxidative stress and cytotoxicity in human bronchial epithelial cells BEAS-2B. Experimental results suggested that DJ-1 and cofilin proteins were protein biomarkers for tt-DDE-induced cytotoxicity and oxidative stress in lung cells. DJ-1 was especially an early biomarker for tt-DDE exposure. ? 2008 Elsevier Inc. All rights reserved.
    日期: 2008-11-21
    關聯: Biochemical and Biophysical Research Communications. 2008 Nov 21;376(3):519-524.
    Link to: http://dx.doi.org/10.1016/j.bbrc.2008.09.020
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-291X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000260159000015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=53149134254
    显示于类别:[張惠華(1999-2009)] 期刊論文
    [林嬪嬪] 期刊論文

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