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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/3492
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| Title: | Perforation predicts poor prognosis in patients with primary intestinal diffuse large B-cell lymphoma |
| Authors: | Chuang, SS;Ye, H;Yang, SF;Huang, WT;Chen, HK;Hsieh, PP;Hwang, WS;Chang, KY;Lu, CL;Du, MQ |
| Contributors: | National Institute of Cancer Research |
| Abstract: | Aims: To elucidate the clinicopathological features and prognostic factors of primary intestinal diffuse large B-cell lymphoma (PI-DLBL). Methods and results: Archival tissues from 30 tumours were used for tissue microarray construction, immunohistochemistry and interphase fluorescence in situ hybridization for chromosomal translocation. The M:F ratio was 1.7:1, with a median age of 60 years. The ileum and ileocaecum were most frequently involved (40% each). Fourteen (47%) were at stage IE disease, 15 (50%) at stage IIE. Five (17%) tumours were perforated at presentation. The tumours expressed Bcl-6 (73%), MUM1 (70%), Bcl-2 (67%) and CD10 (23%). Nine (30%) were classified as germinal centre B-cell (GCB) phenotype and 21 non-GCB. Eight of 30 (27%), 7/30 (23%) and 2/29 (7%) cases were positive for rearrangements involving IGH, BCL6, and C-MYC loci, respectively, whereas all cases were negative for BCL2 and CCND1 translocation. Perforation was a poor prognostic indicator, with a hazard ratio of tumour-related death at 8.75 (P = 0.001). The differentiation antigens, GCB versus non-GCB phenotype, or lymphoma-associated translocations were of no prognostic significance. Conclusions: We found a higher rate of perforation and lower frequency of GCB phenotype in PI-DLBL in Taiwan compared with other geographical areas; perforation is a poor prognostic indicator. ? 2008 The Authors. |
| Date: | 2008-10 |
| Relation: | Histopathology. 2008 Oct;53(4):432-440. |
| Link to: | http://dx.doi.org/10.1111/j.1365-2559.2008.03140.x |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0309-0167&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000259524700008 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=52649096885 |
| Appears in Collections: | [張光裕] 期刊論文
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| SCP52649096885.pdf | | 384Kb | Adobe PDF | 701 | View/Open |
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