國家衛生研究院 NHRI:Item 3990099045/3540
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    题名: Ligand binding of leukocyte integrin very late antigen-4 involves exposure of sulfhydryl groups and is subject to redox modulation
    作者: Liu, SY;Tsai, MY;Chuang, KP;Huang, YF;Shieh, CC
    贡献者: Division of Clinical Research
    摘要: Activation of leukocyte integrins is important for selective recruitment of cells from the circulation to tissues. Our previous studies showed that the binding between the integrin very late antigen-4 (VLA-4) and vascular cell adhesion molecule-1 (VCAM-1) is modulated by reactive oxygen species. In this study, we investigated the molecular nature of redox modulation on the activation states of VLA-4 on. human leukocytes. We found that ligand binding of VLA-4 induced exposure of sulfhydryl groups on the 帢4 peptide. Low concentrations (5-10 弮M) of exogenous hydrogen peroxide in the presence or absence of added glutathione enhanced the ligand binding ability of VLA-4 to VCAM-1. and cell rolling on VCAM-1, while higher concentrations (??00 弮M) of hydrogen peroxide inhibited the binding. Exogenous hydrogen peroxide and glutathione induced molecular modification of S-glutathionylation on the 帢4 peptide. The redox regulation of the VLA-4 binding activity required outside-in signaling and cytoskeleton rearrangement. Our results indicate that ligand binding of VLA-4 involves redox modulations which may play a pivotal role in regulating the activation states of VLA-4 in inflammatory tissues and hence direct leukocyte trafficking. 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
    日期: 2008-02
    關聯: European Journal of Immunology. 2008 Feb;38(2):410-423.
    Link to: http://dx.doi.org/10.1002/eji.200737556
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-2980&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000253326100011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=42249089210
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