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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3546


    Title: Expression of the HCRP1 mRNA in HCC as an independent predictor of disease-free survival after surgical resection
    Authors: Lai, MW;Huang, SF;Lin, SM;Chen, TC;Lin, CY;Yeh, CN;Yeh, TS;Chen, MF;Yeh, CT
    Contributors: Division of Molecular and Genomic Medicine
    Abstract: Aim: Hepatocellular carcinoma (HCC)-related protein-1 (HCRP1) gene was located at chromosome 8p22, a frequently deleted region in HCC. The gene product was a subunit of mammalian Endosomal Sorting Complex Required for Transport (ESCRT)-I, essential for degradation of epidermal growth factor receptors. In this study, we examined the prognostic role of HCRP1 mRNA expression in HCC. Methods: The expression of HCRP1 mRNA in HCC was assessed in 125 patients receiving surgical resection of HCC. Using the adjacent non-cancerous tissues as a reference, 55 and 70 patients expressing high and low levels of HCRP1 mRNA, respectively, were identified. The predictive value of HCRP1 mRNA expression in postoperative survival was evaluated. Results: Expression of HCRP1 mRNA was not associated with any of the baseline clinicopathological parameters. However, univariate analysis showed that it was associated with a better disease-free survival (P < 0.001) and overall survival (P = 0.032). Stepwise Cox multivariate proportional hazards regression analysis showed that the expression of HCRP1 mRNA (hazard ratio [HR], 0.396; 95% confidence interval (CI), 0.233 - 0.674; P = 0.001), tumor number (HR, 1.596; 95% CI, 1.221 - 2.087; P = 0.001), serum aspartate aminotransferase (HR, 1.002; 95% CI, 1.000 - 1.003; P = 0.031) and the presence of microvascular invasion (HR, 1.852; 95% CI, 1.131 - 3.032; P = 0.014) were included as independent predictors for disease-free survival. Conclusion: Expression of HCRP1 mRNA served as an independent predictor for postoperative disease-free survival in HCC patients. ? 2009 The Japan Society of Hepatology.
    Date: 2009-02
    Relation: Hepatology Research. 2009 Feb;39(2):164-176.
    Link to: http://dx.doi.org/10.1111/j.1872-034X.2008.00413.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1386-6346&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000262640700008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=59149098261
    Appears in Collections:[Shiu-Feng Kathy Huang] Periodical Articles

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