國家衛生研究院 NHRI:Item 3990099045/3561

NHRI > National Institute of Infectious Diseases and Vaccinology > Chih-Hsiang Leng > Periodical Articles > Item 3990099045/3561

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3561

Title:	Formulation and immunological evaluation of novel vaccine delivery systems based on bioresorbable poly(ethylene glycol)-block-poly(lactide-co-epsilon-caprolactone)
Authors:	Huang, MH;Chou, AH;Lien, SP;Chen, HW;Huang, CY;Chen, WW;Chong, P;Liu, SJ;Leng, CH
Contributors:	Vaccine Research and Development Center
Abstract:	Novel emulsion-type vaccine delivery systems based on the amphiphilic bioresorbable polymer poly(ethylene glycol)-block-poly(lactide-co-ε- caprolactone) (PEG-b-PLACL) and selected oils were developed here. Physicochemical characterizations such as stability, a droplet test, microscopic aspects, and in vitro release showed that PEG-b-PLACLemulsified formulations have several advantages over traditional vaccine adjuvants in that they are stable, reproducible, and homogeneous fine particles with an appropriate size to facilitate the induction of potent immune responses. Different dispersion-type emulsions have provided different release profiles using ovalbumin in model studies. Immunogenicity studies in mice have shown that antigen-specific antibody titers and T-cell proliferative responses, as well as the secretion of IFN-γ, were significantly enhanced for ovalbumin after formulation with PEG-b-PLACL-based emulsions. These features are of great interest for applications in delivery systems of prophylactic and therapeutic vaccine candidates.
Date:	2009-08
Relation:	Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2009 Aug;90(2):832-841.
Link to:	http://dx.doi.org/10.1002/jbm.b.31352
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1552-4973&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000268114200041
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67749148277
Appears in Collections:	[Chih-Hsiang Leng] Periodical Articles [Pele Choi-Sing Chong] Periodical Articles [Shih-Jen Liu] Periodical Articles [Hsin-Wei Chen] Periodical Articles [Ming-Hsi Huang] Periodical Articles

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