國家衛生研究院 NHRI:Item 3990099045/3564
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    题名: A novel dengue vaccine candidate that induces cross-neutralizing antibodies and memory immunity
    作者: Leng, CH;Liu, SJ;Tsai, JP;Li, YS;Chen, MY;Liu, HH;Lien, SP;Yueh, A;Hsiao, KN;Lai, LW;Liu, FC;Chong, P;Chen, HW
    贡献者: Vaccine Research and Development Center;Division of Biotechnology and Pharmaceutical Research
    摘要: A novel dengue vaccine candidate comprised of a consensus dengue virus envelope protein domain III (cED III) was developed to fight against dengue virus infection. The amino acid sequence of this novel cED III was obtained by alignment of amino acid sequences from different isolates of the four serotypes of dengue viruses. A proof-of-concept study demonstrated that BALB/c mice immunized with the recombinant cED III developed neutralizing antibodies against all serotypes of dengue virus. Moreover, formulation of recombinant cED III with aluminum phosphate could induce long-lasting antibody responses and anamnestic neutralizing antibody responses following challenge with dengue virus at week 28 after priming. These results demonstrate the possibility of developing a single tetravalent vaccine against dengue viral infections.
    日期: 2009-02
    關聯: Microbes and Infection. 2009 Feb;11(2):288-295.
    Link to: http://dx.doi.org/10.1016/j.micinf.2008.12.004
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1286-4579&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000264993100018
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=59649115889
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