國家衛生研究院 NHRI:Item 3990099045/3573
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    题名: Strain-dependent inflammatory responsiveness of rat microglial cells
    作者: Wei, R;Lin, CM
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: The aim of this study is to test whether inflammatory responsiveness of rat microglial cells is strain-specific in primary microglia derived from neonatal LEW/N and F344/N rats. In contrast to F344/N microglia, LEW/N microglia constitutively and upon lipopolysaccharide challenge expressed higher levels of mRNA for the majority of inflammatory mediators studied. In addition, LEW/N microglia exhibited enhanced secretion of tumor necrosis factor-α and CCL2, as well as elevated nitric oxide production. On the contrary, activated LEW/N microglia transcribed and secreted less interleukin-10. Hence, compared to F344/N microglia, LEW/N microglia might be more reactive to lipopolysaccharide and incompetent to suppress inflammation.
    日期: 2009-06-25
    關聯: Journal of Neuroimmunology. 2009 Jun 25;211(1-2):23-38.
    Link to: http://dx.doi.org/10.1016/j.jneuroim.2009.03.007
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0165-5728&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000268035000003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67349202711
    显示于类别:[魏榮泰(2004-2010)] 期刊論文

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