Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/3583
|
| Title: | Phase II study of biweekly gemcitabine followed by oxaliplatin and simplified 48-h infusion of 5-fluorouracil/leucovorin (GOFL) in advanced pancreatic cancer |
| Authors: | Ch'ang, HJ;Huang, CL;Wang, HP;Shiah, HS;Chang, MC;Jan, CM;Chen, JS;Tien, YW;Hwang, TL;Lin, JT;Cheng, AL;Whang-Peng, J;Chen, LT |
| Contributors: | National Institute of Cancer Research |
| Abstract: | Purpose: To evaluate the efficacy and safety profile of a triplet regimen consisting of gemcitabine, oxaliplatin, and infusional fluorouracil and leucovorin (LV) in advanced pancreatic carcinoma (APC). Patients and methods: Chemotherapy-naive patients with histo-/cytologically proven unresectable APC, and bi-dimensionally measurable diseases were eligible. Treatment consisted of fixed-dose rate (10 mg/m2/min) infusion of 800 mg/m2 gemcitabine followed by 2-h infusion of 85 mg/m2 oxaliplatin and then 48-h infusion of fluorouracil and LV (3,000 and 300 mg/m2, respectively) every 2 weeks (the GOFL regimen). The primary end-point was objective response rate. Results: Forty-five patients were enrolled and received a median of seven [95% confidence interval (CI) 6.4-8.8] cycles of treatment. On intent-to-treat analysis, the overall response and disease-control rates were 33.3% (95% CI 21.4-48.0%) and 68.9% (95% CI 54.8-83.0%), respectively. Clinical benefit response was observed in 46.2% of initially symptomatic patients. The median time-to-tumor progression and overall survival were 5.1 (95% CI 4.0-6.3) months and 8.7 (95% CI, 6.1-11.3) months, respectively. Major grade 3-4 toxicities were neutropenia (28.9%, with 4.4% complicated with fever), peripheral sensory neuropathy (15.6%), nausea/vomiting (13.3%), and diarrhea (6.7%). Conclusions: The triplet regimen is feasible and exhibits promising activity against APC, deserving further exploration. |
| Date: | 2009-11 |
| Relation: | Cancer Chemotherapy and Pharmacology. 2009 Nov;64(6):1173-1179. |
| Link to: | http://dx.doi.org/10.1007/s00280-009-0980-2 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0344-5704&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000269112600014 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=69049099928 |
| Appears in Collections: | [陳立宗] 期刊論文
[夏和雄(1996-2012)] 期刊論文
[常慧如] 期刊論文
[彭汪嘉康(1996-2007)] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| SCP69049099928.pdf | | 327Kb | Adobe PDF | 870 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
