國家衛生研究院 NHRI:Item 3990099045/3586
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    題名: Prognostic significance of beta-catenin and topoisomerase II alpha in de novo acute myeloid leukemia
    作者: Chen, CG;Gau, JP;You, JY;Lee, KD;Yu, AB;Lu, CH;Lin, JT;Lan, C;Lo, WH;Liu, JM;Yang, CF
    貢獻者: National Institute of Cancer Research
    摘要: The Wnt/β-catenin signaling is important for controlling self-renewal of hematopoietic stem cells and its constitutive activation has recently been documented in a significant proportion of acute myeloid leukemia (AML) cases. Topoisomerase IIα (Topo IIα) is a marker of cell proliferation and a crucial target for anthracycline cytotoxicity, the mainstay of management employed in AML. We retrospectively investigated the prognostic roles of β-catenin and topo IIα in a cohort of 59 patients with newly diagnosed AML by immunohistochemistry. Aberrant β-catenin expression was demonstrated in 13 patients (22%), and it was more likely to occur in those with unfavorable karyotypes. Advanced age and poor performance status adversely influenced the achievement of complete remission, while neither aberrant β-catenin expression nor enhanced topo IIα activity did. On multivariate survival analysis, four factors independently predicted a shortened overall survival: aberrant β-catenin expression, high topo IIα activity, poor-risk cytogenetics, and presence of at least one comorbidity factor. Our results suggest that both β-catenin and topo IIα independently predicted an adverse prognosis and might serve as new markers for risk stratification in AML patients. Am. J. Hematol.
    日期: 2009-02
    關聯: American Journal of Hematology. 2009 Feb;84(2):87-92.
    Link to: http://dx.doi.org/10.1002/ajh.21334
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0361-8609&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000263083600005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=59949096098
    顯示於類別:[劉敏(1996-2007)] 期刊論文

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