國家衛生研究院 NHRI:Item 3990099045/3743
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    題名: Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression
    作者: Wu, CM;Yang, CW;Lee, YZ;Chuang, TH;Wu, PL;Chao, YS;Lee, SJ
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: Tylophorine, a representative phenanthroindolizidine alkaloid from Tylophora indica plants, exhibits anti-inflammatory and anti-cancerous growth activities. However, the underlying mechanisms of its anti-cancer activity have not been elucidated and its effects on cell cycle remain ambiguous. Here, we reveal by asynchronizing and synchronizing approaches that tylophorine not only retards the S-phase progression but also dominantly arrests the cells at G1 phase in HepG2, HONE-1, and NUGC-3 carcinoma cells. Moreover, tylophorine treatment results in down regulated cyclin A2 expression and overexpressed cyclin A2 rescues the G1 arrest by tylophorine. Thus, we are the first to report that the downregulated cyclin A2 plays a vital role in G1 arrest by tylophorine in carcinoma cells.
    日期: 2009-08-14
    關聯: Biochemical and Biophysical Research Communications. 2009 Aug 14;386(1):140-145.
    Link to: http://dx.doi.org/10.1016/j.bbrc.2009.05.138
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-291X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000267868800027
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67649202166
    顯示於類別:[李秀珠] 期刊論文
    [趙宇生(2002-2013)] 期刊論文

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