國家衛生研究院 NHRI:Item 3990099045/3754
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    题名: Immunogenic properties of RSV-B1 fusion (F) protein gene-encoding recombinant adenoviruses
    作者: Shao, HY;Yu, SL;Sia, C;Chen, Y;Chitra, E;Chen, IH;Venkatesan, N;Leng, CH;Chong, P;Chow, YH
    贡献者: Vaccine Research and Development Center
    摘要: Two recombinant adenoviruses designated rAd-F0ΔTM and rAd-F0 carrying the transmembrane truncated and full length of the F gene of the RSV-B1 strain, respectively, were engineered. Comparative immunogenicity studies in BALB/c mice showed that each vector was capable of inducing RSV-B1-specific antibodies that cross-reacted with the RSV-long and RSV-A2 viruses. The anti-RSV-B1 antibodies were neutralizing, and exhibited strong cross-neutralizing activity against the RSV-long and RSV-A2 isolates as well. Analysis of the cellular responses revealed that animals immunized with rAd-F0ΔTM and rAd-F0 elicited CD4+ T-cell responses of the Th1 and Th2 phenotypes, as well as F protein-specific CTLs. Production of Th2 cytokines (IL-4, IL-5 and IL-13) by splenocytes of the rAd-F0ΔTM and rAd-F0 immunized mice was markedly lower than those released by animals administered with heat-inactivated RSV-B1 (HIRSV-B1). Comparison of the overall humoral and cellular responses suggests that rAd-F0ΔTM is significantly more immunogenic than rAd-F0. The anti-viral immunity generated by both recombinant adenovirus vectors has conferred protection against live RSV-B1 challenge as judged by the lower viral load recovered in the lungs, a faster rate of recovery of body weight loss, and a lower count of eosinophils as compared to eosinophilia in mice immunized with HIRSV-B1. Results from these studies suggest that rAd-F0ΔTM or rAd-F0 possess immunogenic properties that meet the requirements expected from potential RSV vaccine candidates.
    日期: 2009-09-04
    關聯: Vaccine. 2009 Sep 4;27(40):5460-5471.
    Link to: http://dx.doi.org/10.1016/j.vaccine.2009.07.004
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0264-410X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000269682800007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=68549132243
    显示于类别:[周彥宏] 期刊論文
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