國家衛生研究院 NHRI:Item 3990099045/3755
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3755


    Title: F-spondin plays a critical role in murine neuroblastoma survival by maintaining IL-6 expression
    Authors: Cheng, YC;Liang, CM;Chen, YP;Tsai, IH;Kuo, CC;Liang, SM
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: F-spondin is associated with the regulation of axonal growth and the development of the nervous system. Its mechanism of action, however, is not clearly understood. In this study, we found that murine neuroblastoma Neuro-2a cells expressed a significant level of IL-6, but only trace amounts of IL-12, tumor necrosis factor α and nitric oxide. Knock-down of F-spondin mRNA in murine neuroblastoma NB41A3 and Neuro-2a cells using small interfering RNAs led to decreased IL-6 levels along with lower resistance to serum starvation and cytotoxic amyloid β1-42 (Aβ1-42) peptide. Restoring decline of F-spondin or IL-6 induced by F-spondin knock-down through adding exogenous F-spondin, IL-6 or over-expressing F-spondin reversed the cell death induced by Aβ1-42 peptide or serum starvation. The decrease of IL-6 level was positively correlated with decrease of NF-κB and inhibition of p38 mitogen-activated protein kinase (MAPK). Over-expressing MEKK, a kinase activator of the p38 MAPK pathway, increased IL-6 production, restored the decrease of p38 induced by F-spondin knock-down, and rescued the cells from death caused by Aβ1-42 peptide. Taken together, these results suggest that F-spondin may play a critical role in murine neuroblastoma survival under adverse conditions by maintaining IL-6 level via a MEKK/p38 MAPK/NF-κB-dependent pathway.
    Date: 2009-08
    Relation: Journal of Neurochemistry. 2009 Aug;110(3):947-955.
    Link to: http://dx.doi.org/10.1111/j.1471-4159.2009.06186.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-3042&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000267968700017
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67650481462
    Appears in Collections:[Cheng-Chin Kuo] Periodical Articles
    [Chi-Ming Liang(2007-2009)] Periodical Articles

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