國家衛生研究院 NHRI:Item 3990099045/3760
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3760


    Title: Aberrant expression of cyclin A correlates with morphogenesis of Reed-Sternberg cells in Hodgkin lymphoma
    Authors: Chang, KC;Chang, Y;Jones, D;Su, IJ
    Contributors: Division of Infectious Diseases
    Abstract: Reed-Sternberg (RS) cells represent a histopathologic hallmark for Hodgkin lymphoma (HL). Viral proteins may induce aberrant expression of cyclin A and lead to multinucleation in virus-infected cells. We investigated whether Epstein-Barr virus (EBV) latent membrane protein-1 (LMP1) and cyclin A are involved in the morphogenesis of RS cells. We immunohistochemically analyzed "individual" tumor cells in 34 HLs for the subcellular expression of cyclin A and HL-related markers. In LMP1+ and LMP1- HLs, multinucleated RS cells aberrantly expressed cyclin A in cytoplasm, while the mononuclear Hodgkin cells expressed cyclin A predominantly in nuclei (P < .001). No differential expression of CD15, CD30, or CD99 in HL cells was found. In vitro, EBV-LMP1 increased cytoplasmic cyclin A expression and multinucleation in an HL cell line. Therefore, the aberrant expression of cyclin A is commonly associated with RS cell morphologic features in HL, probably through LMP1 signaling or other similar mechanisms in EBV - cases.
    Date: 2009-07
    Relation: American Journal of Clinical Pathology. 2009 Jul;132(1):50-59.
    Link to: http://dx.doi.org/10.1309/ajcpbdfr5l5uoauz
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-9173&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000267206400008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67650471361
    Appears in Collections:[Ih-Jen Su(2002-2015)] Periodical Articles
    [Yao Chang] Periodical Articles

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