國家衛生研究院 NHRI:Item 3990099045/3761
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3761


    Title: Involvement of Nigrostriatal Pathway in Japanese Encephalitis with Movement Disorders: Evidence from 99mTc-TRODAT-1 and 123I-IBZM SPECT Imagings
    Other Titles: Involvement of Nigrostriatal Pathway in Japanese Encephalitis with Movement Disorders: Evidence from Tc-99m-TRODAT-1 and I-123-IBZM SPECT Imagings
    Authors: Liao, CH;Ling, Z;Chou, CH;Huang, WS;Denq, JC;Lin, JC;Chen, CY;Chang, CJ;Peng, GS
    Contributors: Division of Mental Health and Substance Abuse Research
    Abstract: Purpose: The purpose of this study was to evaluate molecular evidence of nigrostriatal pathway involvement in Japanese encephalitis (JE) survivors with movement complications. Methods: Three JE patients were recruited. All had cranial magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) studies with 99mTc-TRODAT-1 and 123I-IBZM. Results: Cranial MRI revealed involvement of bilateral thalami, substantia nigra, and medial temporal lobes in all three patients, but only case 1 had additional bilateral basal ganglia involvement. The 99mTc-TRODAT-1 SPECT for presynaptic dopamine transporter imaging disclosed asymmetrical decreases in bilateral striatal uptake in all three patients. However, the 123I-IBZM SPECT imaging for postsynaptic D2 dopamine receptors (D2Rs) revealed inconsistent abnormalities including asymmetrical bilateral decreases (case 1), unilateral decrease (case 2), and bilateral increases (case 3) in striatal uptakes. Conclusion: Data have suggested that presynaptic dopaminergic neurons in JE patients are more susceptible to JE virus than postsynaptic striatal neurons. The degree of movement impairment was more closely correlated to the degree of D2Rs disruption seen in 123I-IBZM SPECT imaging.
    Date: 2010-02
    Relation: Molecular Imaging and Biology. 2010 Feb;12(1):9-14.
    Link to: http://dx.doi.org/10.1007/s11307-009-0244-x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1536-1632&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000273479300003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77149143885
    Appears in Collections:[Zaodung Ling(2006-2009)] Periodical Articles

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