國家衛生研究院 NHRI:Item 3990099045/3799
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    题名: A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.]
    其它题名: A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors (vol 43, pg 1603, 2008)
    作者: Lu, IL;Tsai, KC;Chiang, YK;Jiaang, WT;Wu, SH;Mahindroo, N;Chien, CH;Lee, SJ;Chen, X;Chao, YS;Wu, SY
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: Dipeptidyl peptidase IV (DPP-IV) is a valid drug target for type-2 diabetes and DPP-IV inhibitors have been proven to efficiently improve glucose tolerance. In our study, 3D pharmacophore models were generated using a training set of 22 DPP-IV inhibitors. The best model consisted of important chemical features and mapped well into the active site of DPP-IV. The model gave high correlation coefficients of 0.97 and 0.84 for the training set and the test set, respectively, showing its good predictive ability for biological activity. Furthermore, the pharmacophore model demonstrated the capability to retrieve inhibitors from database with a high enrichment factor of 42.58. All results suggest that the model provides a useful tool for designing novel DPP-IV inhibitors.
    日期: 2009-06
    關聯: European Journal of Medicinal Chemistry. 2009 Jun;44(6):2763-2763.
    Link to: http://dx.doi.org/10.1016/j.ejmech.2008.09.008
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0223-5234&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000266030800056
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=64549145874
    显示于类别:[伍素瑩] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [李秀珠] 期刊論文
    [蔣維棠] 期刊論文
    [陳新(2002-2015)] 期刊論文

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