國家衛生研究院 NHRI:Item 3990099045/3836
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12189/12972 (94%)
造訪人次 : 956708      線上人數 : 835
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3836


    題名: IL-6-transfected tumor cells modulate the status of CD8+ and CD4+ T cells to control tumor growth
    作者: Hsieh, CL;Liu, SJ;Shen, CR;Chen, MY;Hsu, SC;Tsai, JP;Li, YS;Yang, CJ;Chong, P;Chen, HW
    貢獻者: Vaccine Research and Development Center
    摘要: IL-6 is a proinflammatory cytokine secreted by tumor cells and immune cells to affect the development of cancer. This study demonstrates the effects of tumor-derived IL-6 on the malignancy of tumor cells and tumor immunity. The tumor cell line, EG7, was transfected with a mammalian expression vector encoding the full length of murine IL-6 to mimic IL-6-secreting tumor cells. Two IL-6 transfectants with low and high IL-6 production were compared in vitro and in vivo. While the in vitro proliferation rates of both transfectants and the parental line were similar, high expression of IL-6 induced a significant reduction in tumor growth in vivo. Concomitantly, there was an increase in IFN-γ positive tumor-infiltrating lymphocytes and a decrease in the suppressive CD4+CD25+FoxP3+ population. These results demonstrate the direct effects of tumor-derived IL-6 on cancer development and the induction of tumor immunity.
    日期: 2010-06
    關聯: Immunobiology. 2010 Jun;215(6):486-491.
    Link to: http://dx.doi.org/10.1016/j.imbio.2009.07.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0171-2985&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000278826000007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952541868
    顯示於類別:[陳信偉] 期刊論文
    [劉士任] 期刊論文
    [莊再成] 期刊論文
    [許素菁] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SCP68749106222.pdf302KbAdobe PDF1436檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋