國家衛生研究院 NHRI:Item 3990099045/3851
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3851


    Title: The association between dementia and long-term use of benzodiazepine in the elderly: Nested case-control study using claims data
    Authors: Wu, CS;Wang, SC;Chang, IS;Lin, KM
    Contributors: National Institute of Cancer Research;Division of Mental Health and Substance Abuse Research
    Abstract: OBJECTIVES: The aim of this study was to examine the association between long-term benzodiazepines (BZDs) use and the risk of dementia. DESIGN: Population-based nested case-control study of dementia. SETTING: All subjects were aged 45 and older and enrolled in the National Health Insurance Research Database in Taiwan, 1997-2004. PARTICIPANTS: Cases (N = 779) were patients who were identified with dementia at least two times in their outpatient claims. They were individually matched to six comparison subjects (N = 4,626) based on age and gender. MEASUREMENTS: BZD usage (average dosage per year, average days per year, and cumulative dose and periods) and potential confounding comobidities, including cardiovascular and psychiatric diseases. RESULTS: Subjects with dementia had higher cumulative dose, longer duration of BZDs exposure, and more likelihood to be long-term BZDs users. CONCLUSION: Our findings suggest that long-term use of BZDs is associated with an increased risk for dementia, but the underlying mechanisms remain unclear, and further investigations are needed. Long-term use of BZDs should be avoided among the elderly, who may be at a higher risk for developing dementia, in addition to other health problems.
    Date: 2009-07
    Relation: American Journal of Geriatric Psychiatry. 2009 Jul;17(7):614-620.
    Link to: http://dx.doi.org/10.1097/JGP.0b013e3181a65210
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1064-7481&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000267582500009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=68049106370
    Appears in Collections:[Keh-Ming Lin(2004-2009)] Periodical Articles
    [I-Shou Chang] Periodical Articles
    [Sheng-Chang Wang] Periodical Articles
    [Chi-Shin Wu] Periodical Articles

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