國家衛生研究院 NHRI:Item 3990099045/3865
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    題名: Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors
    作者: Kang, IJ;Wang, LW;Hsu, SJ;Lee, CC;Lee, YC;Wu, YS;Yueh, A;Wang, JC;Hsu, TA;Chao, YS;Chern, JH
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: A novel class of arylthiourea HCV inhibitors bearing various functionalities, such as cyclic urea, cyclic thiourea, urea, and thiourea, on the alkyl linker were designed and synthesized. Herein we report the synthesis and structure-activity relationships (SARs) of this novel class of arylthiourea derivatives that showed potent inhibitory activities against HCV in the cell-based subgenomic HCV replicon assay. Among compounds tested, the new carbazole derivative 64, which has an eight-carbon linkage between the phenyl and carbazole rings and a tolyl group at the N-9 position of carbazole, was found to possess strong anti-HCV activity (EC50 = 0.031 μM), lower cytotoxicity (CC50 >50 μM), and higher selectivity index (SI >1612) compared to its derivatives.
    日期: 2009-11-01
    關聯: Bioorganic and Medicinal Chemistry Letters. 2009 Nov 1;19(21):6063-6068.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2009.09.037
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000270561300016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=72049097165
    顯示於類別:[陳志豪] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [徐祖安] 期刊論文
    [岳嶽] 期刊論文

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