國家衛生研究院 NHRI:Item 3990099045/3878
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3878


    Title: Pulmonary changes induced by trans, trans-2, 4-decadienal, a component of cooking oil fume
    Authors: Wang, CK;Chang, LW;Chang, H;Yang, CH;Tsai, MH;Tsai, HT;Lin, P
    Contributors: Division of Environmental Health and Occupational Medicine
    Abstract: Cooking oil fume (COF) is known to be associated with respiratory diseases and risk of lung cancer. The involvement of Trans, trans-2,4-decadienal (tt-DDE), a major component in COF, is suspected. Male ICR mice were intratracheally instilled with either 8 or 24 mg.kg(-1) tt-DDE weekly for eight weeks. Total numbers and types of cells in bronchoalveolar lavage fluids (BAL), as well as pathologic changes, and inflammatory gene modulations in the lung tissues were assessed. We demonstrated that the number of alveolar macrophages in the BAL fluids was significantly increased in tt-DDE-exposed animals. Histologically, there was a dose-correlated increase in developments of epithelial hyperplasia and granulomatous nodule at the bronchioloalveolar junctions (BAJ). While both Clara and alveolar type II cells were present in the BAJ lesion, only Clara cells were found to be actively proliferative. On the other hand, only alveolar type II cells were found in the BAJ granulomatous nodules. Furthermore, enhanced accumulation of pSTAT3, a known pro-carcinogenic factor, was also detected in many alveolar type II cells at the BAJ lesions. Since both BAJ hyperplasia and enhanced pSTAT3 accumulation are known risk factors associated with increased lung adenocarcinoma development, these findings suggest that tt-DDE may pose risk in lung carcinogenesis.
    Date: 2010-03
    Relation: European Respiratory Journal. 2010 Mar;35(3):667-675.
    Link to: http://dx.doi.org/10.1183/09031936.00140508
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0903-1936&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000275239000029
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77951147381
    Appears in Collections:[Pinpin Lin] Periodical Articles
    [Louis W. Chang(1999-2009)] Periodical Articles

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