國家衛生研究院 NHRI:Item 3990099045/3896
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    題名: Cisd2 mediates mitochondrial integrity and life span in mammals
    作者: Chen, YF;Kao, CH;Kirby, R;Tsai, TF
    貢獻者: Division of Molecular and Genomic Medicine
    摘要: CISD2, the causative gene for Wolfram syndrome 2 (WFS2), is a previously uncharacterized novel gene. Using a mouse genetic approach, this work demonstrated for the first time that Cisd2 is involved in mammalian life span control. Cisd2 deficiency in mice leads to mitochondrial breakdown and dysfunction; this is accompanied by cell death with autophagic features and these events precede the two earliest manifestations of nerve and muscle degeneration. Together, they lead to a panel of phenotypic features suggestive of premature aging. This work effectively links Cisd2 gene function, mitochondrial integrity and aging in mammals.
    日期: 2009-10-01
    關聯: Autophagy. 2009 Oct 1;5(7):1043-1045.
    Link to: http://www.landesbioscience.com/journals/autophagy/article/9351/
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1554-8627&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000272691100018
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349641035
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