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http://ir.nhri.org.tw/handle/3990099045/3897
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| Title: | TCF7L2 genetic variants and progression to diabetes in the Chinese population: pleiotropic effects on insulin secretion and insulin resistance |
| Authors: | Chang, YC;Chiu, YF;Ho, LLT;Ting, CT;Shih, KC;Curb, JD;Chen, YDI;Li, HY;Chuang, LM |
| Contributors: | Division of Biostatistics and Bioinformatics |
| Abstract: | TCF7L2 genetic variants were associated with progression to type 2 diabetes in Europeans. However, the role of TCF7L2 in type 2 diabetes remained uncertain in Chinese. Seventeen tag single nucleotide polymorphisms were genotyped in 1,094 subjects of Chinese origin from the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance family study. At baseline, the rs7903146 T allele in the exon 4 linkage disequilibrium (LD) block were associated with lower insulinogenic index at 60?min (P?=?0.01), while the rs290481 G allele near the 3′ end was associated with higher 2-h post-challenge glucose (P?=?0.003) and insulin concentration (P?=?0.02), elevated systolic (P?=?0.01) and diastolic blood pressure (P?=?0.006), lower waist circumference (P?=?0.01), and increased steady-state plasma glucose (SSPG) concentration measured with modified insulin suppression test (P?=?0.02). Over an average follow-up period of 5.43?years, participants with the rs7903146 T allele or variants in the same LD block, but not those with the rs290481 G allele, were more likely to progress to diabetes (hazard ratio?=?2.61, 95% confidence interval, 1.27-5.39, P?=?0.009) than were non-carriers. TCF7L2 gene expression was inversely associated with SSPG in human visceral (r?=?-0.73, P?=?0.006) and subcutaneous adipose tissue (r?=?-0.62, P?=?0.03). TCF7L2 may exert pleiotropic effects on insulin secretion or insulin resistance. However, only variants associated with impaired β-cell function predict progression to diabetes in Chinese. |
| Date: | 2010-02 |
| Relation: | Journal of Molecular Medicine. 2010 Feb;88(2):183-192. |
| Link to: | http://dx.doi.org/10.1007/s00109-009-0542-4 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0946-2716&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000275415500014 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77951207164 |
| Appears in Collections: | [邱燕楓] 期刊論文
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