國家衛生研究院 NHRI:Item 3990099045/3935
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    题名: The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells
    其它题名: The expanding roles of ITAM adapters FcR gamma and DAP12 in myeloid cells
    作者: Hamerman, JA;Ni, M;Killebrew, JR;Chu, CL;Lowell, CA
    贡献者: Immunology Research Center
    摘要: Summary: The adapter proteins DAP12 and FcRγ associate with a wide spectrum of receptors in a variety of innate immune cells to mediate intracellular signaling pathways when their cognate receptor is engaged. These adapter proteins are coupled to their receptors through charged residues within the transmembrane regions of the adapter and receptor. DAP12 and FcRγ contain specific protein domains (referred to as immunoreceptor tyrosine-based activation motifs) that serve as the substrates and docking sites for kinases, allowing amplification of intracellular signaling reactions. Recent research has broadened the repertoire of receptors that utilize these adapters for signaling to include not only novel immunoglobulin superfamily members but also cytokine receptors, integrins, and other adhesion molecules. There is abundant evidence that these multifunctional signaling adapters also mediate inhibitory activity, downmodulating signaling from Toll-like receptors and other heterologous receptors. In this review, we discuss the newly described receptors that utilize DAP12 and/or FcRγ adapters to modulate innate immune responses.
    日期: 2009-11
    關聯: Immunological Reviews. 2009 Nov;232(1):42-58.
    Link to: http://dx.doi.org/10.1111/j.1600-065X.2009.00841.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-2896&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000271057600005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70350414455
    显示于类别:[朱清良(2005-2010)] 期刊論文

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