國家衛生研究院 NHRI:Item 3990099045/3971
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 926024      在线人数 : 562
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3971


    题名: Assessment of gene-covariate interactions by incorporating covariates into association mapping
    作者: Chiu, YF;Kao, HY;Chen, YS;Hsu, FC;Yang, HC
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: ABSTRACT : The HLA region is considered to be the main genetic risk factor for rheumatoid arthritis. Previous research demonstrated that HLA-DRB1 alleles encoding the shared epitope are specific for disease that is characterized by antibodies to cyclic citrullinated peptides (anti-CCP). In the present study, we incorporated the shared epitope and either anti-CCP antibodies or rheumatoid factor into linkage disequilibrium mapping, to assess the association between the shared epitope or antibodies with the disease gene identified. Incorporating the covariates into the association mapping provides a mechanism 1) to evaluate gene-gene and gene-environment interactions and 2) to dissect the pathways underlying disease induction/progress in quantitative antibodies.
    日期: 2009-12-15
    關聯: BMC Proceedings. 2009 Dec 15;3(Suppl. 7):Article number S85.
    Link to: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795988/?tool=pubmed
    显示于类别:[邱燕楓] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    PUB20018081.pdf694KbAdobe PDF606检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈