國家衛生研究院 NHRI:Item 3990099045/3979
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    题名: JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration
    作者: Li, JP;Fu, YN;Chen, YR;Tan, TH
    贡献者: Immunology Research Center;Division of Molecular and Genomic Medicine
    摘要: JNK pathway-associated phosphatase (JKAP, also named DUSP22) is expressed in various tissues, indicating that JKAP may have an important biological function. We showed that JKAP localized in the actin filament-enriched region. Expression of JKAP reduced cell migration, whereas a JKAP mutant lacking catalytic activity (JKAP-CS) promoted cell motility. JKAP efficiently removed tyrosine phosphorylation of several proteins. We have identified focal adhesion kinase (FAK) as a substrate of JKAP. Over-expression of JKAP, but not JKAP-CS mutant, decreased FAK phosphorylation at tyrosine 397, 576, and 577 residues in H1299 cells. Consistent with these results, decreasing JKAP expression by RNA interference promoted cell migration and Src-induced FAK phosphorylation. Taken together, this study identified a new role for JKAP in the modulation of FAK phosphorylation and cell motility.
    日期: 2010-02
    關聯: Journal of Biological Chemistry. 2010 Feb;285(8):5472-5478.
    Link to: http://dx.doi.org/10.1074/jbc.M109.060186
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1083-351X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000275327200040
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77949333621
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