國家衛生研究院 NHRI:Item 3990099045/4020
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12500/13673 (91%)
造访人次 : 2478558      在线人数 : 81
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/4020


    题名: Lysosomal cysteine proteinase cathepsin S as a potential target for anti-cancer therapy
    作者: Chang, WSW;Wu, HR;Yeh, CT;Wu, CW;Chang, JY
    贡献者: National Institute of Cancer Research
    摘要: In mammalian cells, cysteine proteinases are localized mainly in the cytoplasm and lysosomal compartments. For lysosomal cysteine proteinases, they are synthesized as inactive zymogens and converted to active forms occurred in the acidic and reducing conditions of late endosomes or lysosomes. Here we review the roles of active lysosomal cysteine proteinases in particular cathepsin S and its importance to many physiological or pathological processes including tumor growth, angiogenesis, and metastasis. Biochemical and clinical studies have shown significant changes in the levels of mRNA expression and enzyme activity of cathepsin S in various cancer tissues and cell lines. Immunologic, molecular and pharmaceutical approaches to alter the expression and proteolytic activity of cathepsin S all provided strong evidence for a causal role of this proteolytic enzyme in tumor progression and invasion. Determination of the X-ray structures of either cathepsin S alone or complexed with inhibitors further offered insights of the active site pocket of cathepsin S, thereby making the rational design of low-molecular weight synthetic inhibitors feasible for anti-cancer drug development and treatment.
    日期: 2007-02-17
    關聯: Journal of Cancer Molecules. 2007 Feb 17;3(1):5-14.
    Link to: http://www.mupnet.com/JOCM%203%281%29%205.htm
    显示于类别:[張俊彥] 期刊論文
    [張文祥] 期刊論文
    [吳成文(1996-2008)] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    NCA2010012601.pdf1100KbAdobe PDF806检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈