國家衛生研究院 NHRI:Item 3990099045/4074
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    题名: Increased bone mass in adult prostacyclin-deficient mice
    作者: Nakalekha, C;Yokoyama, C;Miura, H;Alles, N;Aoki, K;Ohya, K;Morita, I
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Prostaglandins (PGs) are key regulatory factors that affect bone metabolism. Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) regulates bone resorption and bone formation. Prostacyclin (PGI<sub>2</sub>) is one of the major products derived from arachidonic acid by the action of cyclooxygenase and PGI<sub>2</sub> synthase (PGIS). Unlike PGE<sub>2</sub>, there are few reports about the role of PGI<sub>2</sub> in bone regulation. Therefore, we investigated the potential effect of PGI<sub>2</sub> on bone metabolism. We used PGIS knockout (PGIS<sup>-/-</sup>), PGIS heterozygous (PGIS<sup>+/-</sup>), and wild-type mice to investigate the role of PGI<sub>2</sub>. Notably, PGIS <sup>-/-</sup> mice gradually displayed an increase in trabecular bone mass in adolescence. Adult PGIS<sup>-/-</sup> mice showed an increase in trabecular bone volume/tissue volume. Histomorphometric analysis showed that PGIS<sup>-/-</sup> mice displayed increases in both bone formation and bone resorption parameters. Levels of serum osteocalcin and C-telopeptides were increased in adult PGIS<sup>-/-</sup> mice. Furthermore, the increased bone mass patterns were rescued in PGIS<sup>-/tg</sup> mice. In conclusion, adult PGIS<sup>-/-</sup> mice displayed an overall increase in the levels of both bone formation and bone resorption parameters, which suggests that PGI<sub>2</sub> deficiency accelerates high bone turnover activity with a greater increase in bone mass in aging. These results indicated that PGI<sub>2</sub> may contribute to the maintenance of normal bone mass and micro-architecture in mice in age-dependent manner. Our findings demonstrate for the first time that PGI<sub>2</sub> is involved in bone metabolism in vivo.
    日期: 2010-02
    關聯: Journal of Endocrinology. 2010 Feb;204(2):125-133.
    Link to: http://dx.doi.org/10.1677/joe-09-0376
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-0795&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000275528000004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=75149125762
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