國家衛生研究院 NHRI:Item 3990099045/4091
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4091


    Title: Clinical characteristics of G6PD deficiency in infants with marked hyperbilirubinemia
    Authors: Weng, YH;Chiu, YW
    Contributors: Division of Health Policy Research and Development
    Abstract: This study analyzes the clinical features of glucose-6-phosphate dehydrogenase (G6PD) deficiency in infants with marked hyperbilirubinemia. We retrospectively assessed a cohort of 413 infants with peak total serum bilirubin (TSB) level ? 20 mg/dL from 1995 to 2007. The prevalence of G6PD deficiency was proportional to the level of peak TSB: 21.1% (81/383) in 20 mg/dL to 29.9 mg/dL, 45.5% (10/22) in 30 mg/dL to 39.9 mg/dL, and 100% (8/8) in ? 40 mg/dL. Male sex was more common in G6PD deficiency (75.8%). When compared with G6PD-normal infants, those with G6PD deficiency tended to have extreme hyperbilirubinemia (peak TSB level ? 25 mg/dL) and hemoglobin value<13 g/dL (P<0.001). Furthermore, mortality rate was significantly higher in G6PD-deficient infants (3.0%) than in the G6PD-normal counterparts (0.0%). Among 58 of the G6PD-deficient infants who were followed for more than 12 months, 4 developed the classic neurologic manifestations of kernicterus (6.6%). These findings show that G6PD deficiency is an important risk factor of extreme hyperbilirubinemia, death, and kernicterus.
    Date: 2010-01
    Relation: Journal of Pediatric Hematology Oncology. 2010 Jan;32(1):11-14.
    Link to: http://dx.doi.org/10.1097/MPH.0b013e3181c09aec
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1077-4114&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000273458300004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=75749144329
    Appears in Collections:[Ya-Wen Chiu(2005-2013)] Periodical Articles

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