國家衛生研究院 NHRI:Item 3990099045/4113
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    题名: Characterization and emulsifying properties of block copolymers prepared from lactic acid and poly(ethylene glycol)
    作者: Siao, SY;Lin, LH;Chen, WW;Huang, MH;Chong, P
    贡献者: Vaccine Research and Development Center
    摘要: Block copolymers were prepared by the direct polycondensation of an aqueous lactic acid solution on monomethoxy or dihydroxyl poly(ethylene glycol) (PEG) in the absence of a catalyst. The resulting poly(lactic acid) (PLA)-PEG diblock and PLA-PEG-PLA triblock copolymers were characterized by various analytical techniques, including matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS), gel permeation chromatography, and H-1-NMR. The molecular structure between PLA-PEG and PLA-PEG-PLA could be distinguished after the calculation of the repeat unit masses and end-group masses through the MALDI-TOF MS spectra. Interestingly, both copolymers could serve as a hydrophilic emulsifier to stabilize the squalene/water interfaces and yield narrowly distributed oil-in-water nanoparticles. In contrast, the pre-polymer PEG failed to stabilize the squalene/water interface under the same homogenization conditions. These features are of great interest for applications as bioactive agent delivery, especially for candidate vaccine antigens and lipophilic anticancer drugs.
    日期: 2009-10
    關聯: Journal of Applied Polymer Science. 2009 Oct;114(1):509-516.
    Link to: http://dx.doi.org/10.1002/app.30497
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0021-8995&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000268738500060
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952394713
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