國家衛生研究院 NHRI:Item 3990099045/4229
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4229


    Title: mu-Opioid receptor knockout mice are insensitive to methamphetamine-induced behavioral sensitization
    Authors: Shen, X. E.;Purser, C;Tien, LT;Chiu, CT;Paul, IA;Baker, R;Loh, HH;Ho, IK;Ma, TG
    Contributors: Division of Mental Health and Addiction Medicine
    Abstract: Repeated administration of psychostimulants to rodents can lead to behavioral sensitization. Previous studies, using nonspecific opioid receptor (OR) antagonists, revealed that ORs were involved in modulation of behavioral sensitization to methamphetamine (METH). However, the contribution of OR subtypes remains unclear. In the present study, using mu-OR knockout mice, we examined the role of mu-OR in the development of METH sensitization. Mice received daily intraperitoneal injection of drug or saline for 7 consecutive days to initiate sensitization. To express sensitization, animals received one injection of drug (the same as for initiation) or saline on day 11. Animal locomotor activity and stereotypy were monitored during the periods of initiation and expression of sensitization. Also, the concentrations of METH and its active metabolite amphetamine in the blood were measured after single and repeated administrations of METH. METH promoted significant locomotor hyperactivity at low doses and stereotyped behaviors at relative high doses (2.5 mg/kg and above). Repeated administration of METH led to the initiation and expression of behavioral sensitization in wild-type mice. METH-induced behavioral responses were attenuated in the mu-OR knockout mice. Haloperidol (a dopamine receptor antagonist) showed a more potent effect in counteracting METH-induced stereotypy in the mu-OR knockout mice. Saline did not induce behavioral sensitization in either genotype. No significant difference was observed in disposition of METH and amphetamine between the two genotypes. Our study indicated that the mu-opioid system is involved in modulating the development of behavioral sensitization to METH.
    Date: 2010-08
    Relation: Journal of Neuroscience Research. 2010 Aug;88(10):2294-2302.
    Link to: http://dx.doi.org/10.1002/jnr.22386
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0360-4012&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000279706200021
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77953633261
    Appears in Collections:[Ing-Kang Ho(2006-2011)] Periodical Articles

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