國家衛生研究院 NHRI:Item 3990099045/4235
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4235


    Title: Elevated serum dehydroepiandrosterone sulphate level correlates with increased risk for metabolic syndrome in the elderly men
    Authors: Chen, YC;Chang, HH;Wen, CJ;Lin, WY;Chen, CY;Hong, BS;Huang, KC
    Contributors: Division of Gerontology Research
    Abstract: P>Background The previous studies regarding the association between endogenous dehydroepiandrosterone (DHEA) sulphate level and metabolic syndrome are inconsistent. This study aimed to investigate such relationship in elderly Taiwanese men. Materials and methods Five hundred and eighty-five elderly Taiwanese men (mean age 68 center dot 7 +/- 8 center dot 3 years) were enrolled as the baseline cohort population in 2000. In addition to a questionnaire, body mass index (BMI), blood pressure, fasting blood glucose, lipids, albumin and serum DHEA-S levels were measured for each participant. Metabolic syndrome was based on the definition by the America Heart Association/National Heart Lung Blood Institute. Results The prevalence of metabolic syndrome was 33 center dot 3%. Using multivariate logistic regression analyses with adjustments for age, smoking, alcohol, physical activities, albumin and BMI, there was a positive relationship between serum DHEA-S level and metabolic syndrome. The highest DHEA-S quartile group had increased risk for metabolic syndrome (odds ratio = 2 center dot 68, 95% confidence interval: 1 center dot 44-5 center dot 01, P < 0 center dot 01) compared with the lowest quartile group. The mean serum DHEA-S level increased with increasing number of metabolic syndrome components. Conclusions The prevalence of metabolic syndrome increases with elevated DHEA-S levels among elderly Taiwanese men. Thus, elevated serum DHEA-S level should be treated as an important risk factor for metabolic syndrome in elderly men.
    Date: 2010-03
    Relation: European Journal of Clinical Investigation. 2010 Mar;40(3):220-225.
    Link to: http://dx.doi.org/10.1111/j.1365-2362.2009.02248.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-2972&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000274953000005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77649211752
    Appears in Collections:[Ching-Yu Chen(2006-2010)] Periodical Articles
    [Kuo-Chin Huang] Periodical Articles

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