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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4242


    Title: Reduction of monocyte chemoattractant protein-1 and interleukin-8 levels by ticlopidine in TNF-alpha stimulated human umbilical vein endothelial cells
    Authors: Hu, CJ;Lee, YL;Shih, NY;Yang, YY;Charoenfuprasert, S;Dai, YS;Chang, SM;Tsai, YH;Tseng, H;Liu, CY;Leu, SJ
    Contributors: National Institute of Cancer Research
    Abstract: Atherosclerosis and its associated complications represent major causes of morbidity and mortality in the industrialized or Western countries. Monocyte chemoattractant protein-1 (MCP-1) is critical for the initiating and developing of atherosclerotic lesions. Interleukin-8 (IL-8), a CXC chemokine, stimulates neutrophil chemotaxis. Ticlopidine is one of the antiplatelet drugs used to prevent thrombus formation relevant to the pathophysiology of atherothrombosis. In this study, we found that ticlopidine dose-dependently decreased the mRNA and protein levels of TNF-alpha-stimulated MCP-1, IL-8, and vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs). Ticlopidine declined U937 cells adhesion and chemotaxis as compared to TNF-alpha stimulated alone. Furthermore, the inhibitory effects were neither due to decreased HUVEC viability, nor through NF-kB inhibition. These results suggest that ticlopidine decreased TNF-alpha induced MCP-1, IL-8, and VCAM-1 levels in HUVECs, and monocyte adhesion. Therefore, the data provide additional therapeutic machinery of ticlopidine in treatment and prevention of atherosclerosis.
    Date: 2009
    Relation: Journal of Biomedicine and Biotechnology. 2009;2009:Article number 917837.
    Link to: http://dx.doi.org/10.1155/2009/917837
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000274892600001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=75149190143
    Appears in Collections:[施能耀] 期刊論文

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