國家衛生研究院 NHRI:Item 3990099045/4242
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    題名: Reduction of monocyte chemoattractant protein-1 and interleukin-8 levels by ticlopidine in TNF-alpha stimulated human umbilical vein endothelial cells
    作者: Hu, CJ;Lee, YL;Shih, NY;Yang, YY;Charoenfuprasert, S;Dai, YS;Chang, SM;Tsai, YH;Tseng, H;Liu, CY;Leu, SJ
    貢獻者: National Institute of Cancer Research
    摘要: Atherosclerosis and its associated complications represent major causes of morbidity and mortality in the industrialized or Western countries. Monocyte chemoattractant protein-1 (MCP-1) is critical for the initiating and developing of atherosclerotic lesions. Interleukin-8 (IL-8), a CXC chemokine, stimulates neutrophil chemotaxis. Ticlopidine is one of the antiplatelet drugs used to prevent thrombus formation relevant to the pathophysiology of atherothrombosis. In this study, we found that ticlopidine dose-dependently decreased the mRNA and protein levels of TNF-alpha-stimulated MCP-1, IL-8, and vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs). Ticlopidine declined U937 cells adhesion and chemotaxis as compared to TNF-alpha stimulated alone. Furthermore, the inhibitory effects were neither due to decreased HUVEC viability, nor through NF-kB inhibition. These results suggest that ticlopidine decreased TNF-alpha induced MCP-1, IL-8, and VCAM-1 levels in HUVECs, and monocyte adhesion. Therefore, the data provide additional therapeutic machinery of ticlopidine in treatment and prevention of atherosclerosis.
    日期: 2009
    關聯: Journal of Biomedicine and Biotechnology. 2009;2009:Article number 917837.
    Link to: http://dx.doi.org/10.1155/2009/917837
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000274892600001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=75149190143
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