國家衛生研究院 NHRI:Item 3990099045/4274
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    题名: Schizosaccharomyces pombe possesses two paralogous valyl-tRNA synthetase genes of mitochondrial origin
    作者: Chiu, WC;Chang, CP;Wen, WL;Wang, SW;Wang, CC
    贡献者: Division of Molecular and Genomic Medicine
    摘要: Previous studies showed that VAS1 of Saccharomyces cerevisiae encodes both cytosolic and mitochondrial forms of valyl-tRNA synthetase (ValRS) through alternative initiation of translation. We show herein that except for Schizosaccharomyces pombe, all yeast species studied contained a single ValRS gene encoding both forms, and all of the mature protein forms deduced from those genes possessed an N-terminal appended domain which was absent from their bacterial relatives. In contrast, S. pombe contained two distinct nuclear ValRS genes, one encoding the mitochondrial form and the other its cytosolic counterpart. While the cytosolic form closely resembles other yeast ValRS sequences ( approximately 60% identity), the mitochondrial form exhibits significant divergence from others ( approximately 35% identity). Both genes are active and essential for the survival of the yeast. Most conspicuously, the mitochondrial form lacks the characteristic appended domain. A phylogenetic analysis further suggested that both forms of S. pombe ValRS are of mitochondrial origin, and the mitochondrial form is ancestral to the cytoplasmic form.
    日期: 2010-06
    關聯: Molecular Biology and Evolution. 2010 Jun;27(6):1415-1424.
    Link to: http://dx.doi.org/10.1093/molbev/msq025
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0737-4038&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000277991900018
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952860118
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