國家衛生研究院 NHRI:Item 3990099045/4407
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    題名: Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide
    作者: Kuo, CC;Liang, CM;Lai, CY;Liang, SM
    貢獻者: Division of Molecular and Genomic Medicine
    摘要: Unmethylated CpG oligodeoxynucleotides (CpG ODNs) activate immune responses in a TLR9-dependent manner. In this study, we found that stimulation of mouse macrophages and dendritic cells with B-type CpG ODN (CpG-B ODN) increased the cellular level of heat shock protein (Hsp) 90 beta but not Hsp90 alpha and prevented apoptosis induced by serum starvation or staurosporine treatment. The CpG-B ODN-induced Hsp90 beta expression depended on TLR9, MyD88, and PI3K. Inhibition of Hsp90 beta level by expressing small-interfering RNA suppressed not only Hsp90 beta expression but also PI3K-dependent phosphorylation of Akt and CpG-B ODN-mediated antiapoptosis. Additional studies demonstrated that as described by other group in mast cells, Hsp90 beta but not Hsp90a was associated with Bcl-2. Inhibition of Hsp90 beta suppressed the CpG-B ODN-induced association of Hsp90 beta with Bcl-2 and impaired the inhibitory effect of CpG-B ODN in the release of cytochrome c and activation of caspase-3. This study thus reveals the involvement of Hsp90 beta but not Hsp90 alpha in CpG-B ODN-mediated antiapoptotic response and that Hsp90 beta is distinct from Hsp90 alpha in regulation of the cellular function of immune cells. The Journal of Immunology, 2007, 178: 6100-6108.
    日期: 2007-05
    關聯: Journal of Immunology. 2007 May;178(10):6100-6108.
    Link to: http://www.ncbi.nlm.nih.gov/pubmed/17475835
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-1767&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000246286200013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34248214192
    顯示於類別:[梁啟銘(2006-2007)] 期刊論文

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