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http://ir.nhri.org.tw/handle/3990099045/4412
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| Title: | Effect of age on pulmonary metastases and immunotherapy in young and middle-aged mice |
| Authors: | Chen, YM;Wang, PS;Liu, JM;Hsieh, YL;Tsai, CM;Perng, RP;Whang-Peng, J |
| Contributors: | National Institute of Cancer Research |
| Abstract: | Background: We used B16-F1O (B16) melanoma tumor cells and syngeneic C57BL/6 (B6) mice as a study model for pulmonary metastases, to better understand whether or not there exist differences in tumorigenicity and in the effectiveness of immunotherapy as a function of host age (1-, 3-, 12- and 24-month-old). Methods: Intravenous injection of B16 melanoma cells were administered to B6 mice of different ages with/without interleukin (IL)-2 and IL-12 daily treatment. Tumor growth, splenocyte function, serum cytokines (IL-10, interferon-γ, vascular endothelial growth factor) and survival were compared. Results: The study showed that, without IL-2 and IL-12 treatment, middle-aged mice suffering from pulmonary metastases had fewer pulmonary metastases and better survival than younger mice suffering from pulmonary metastases. Three days' IL-2 plus IL-12 treatment could not prolong mice survival, but prolonged treatment significantly improved the survival of both the younger and older tumor-bearing mice, especially the older mice, despite the fact that the younger mice had a better serum cytokine and splenocyte cellular immune response to cytokine treatment. Conclusion: The young B6 mice that suffered from B16 pulmonary metastases had a poorer prognosis than the middle-aged mice. Short-term IL-2 plus IL-12 treatment is ineffective in prolonging survival, and a longer duration of treatment is needed. This kind of immunotherapy was effective in both the young and middle-aged mice, but it was more effective in the middle-aged mice. |
| Date: | 2007-03 |
| Relation: | Journal of the Chinese Medical Association. 2007 Mar;70(3):94-102. |
| Link to: | http://dx.doi.org/10.1016/S1726-4901(09)70338-7 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1726-4901&DestApp=IC2JCR |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34247382458 |
| Appears in Collections: | [彭汪嘉康(1996-2007)] 期刊論文
[劉敏(1996-2007)] 期刊論文
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| SCP34247382458.pdf | | 134Kb | Adobe PDF | 773 | View/Open |
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