國家衛生研究院 NHRI:Item 3990099045/4436
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    題名: N-acetylated chitooligosaccharides inhibit TNF-alhpa-induced E-selectin expression in endothelial cells via the JNK-NF-kappa B pathways
    其他題名: N-acetylated chitooligosaccharides inhibit TNF-α-induced E-selectin expression in endothelial cells via the JNK-NF-κB pathways
    作者: Lin, C;Chen, L;Lee, C;Lee, P;Chiu, J
    貢獻者: Division of Medical Engineering Research
    摘要: The anti-inflammatory properties of highly N-acetylated chitooligosaccharides (NACOS) were explored for their potential medical applications. To analyze the effects of NACOS on tumor necrosis factor-α (TNF-α)-induced E-selectin expression, human umbilical vein endothelial cells (ECs) were pre-treated with NACOS with varied concentrations (50, 200, 500 μg/mL) for 1 day before activation by TNF-α for 4 hours. The phosphorylation of different mitogen-activated protein kinases (MAPKs) were examined by Western blot analysis. The effects of NACOS on the E-selectin promoter activity induced by TNF-α were examined by luciferase assay. The chromatin immunoprecipitation (ChIP) assay was performed to investigate the in vivo regulation of nuclear factor-κB (NF-κB) binding to the promoter regions of E-selectin in these ECs by using antibodies against p65 subunit of NF-κB and the promoter-specific primers. Overall, results show that NACOS inhibits TNF-α-induced E-selectin expression in ECs and that this inhibitory effect is mediated through the JNK/NF-κB signaling pathways.
    日期: 2006-12
    關聯: Molecular and Cellular Biomechanics. 2006 Dec;3(4):165-166.
    Link to: http://www.techscience.com/mcb/2006/v3n4_index.html
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33846419140
    顯示於類別:[裘正健] 期刊論文

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