Aims. We evaluate the influency stage migration in a randomised trial comparing D1 (N1 lymphadenectomy) and D3 (N 1, 2 and 3 lymphadenectomy) dissections. Methods. Two hundred and thirteen curatively resected patients were analysed, with this TNM data. Results. After applying D3 patients' data according to simulated 01 staging, D3 resections were associated with up-staging to N2-3 levels in 8% of patients according to the N stage. The likelihood of N-status migration increased with increasing depth of invasion into the gastric wall. The increases in the calculated survival rate after stage migration on known 5-year survival rates were: 2% in stage IIB, 1%, in stage 11, 4% in stage IIIA, and 1% in stage IIIB. Conclusions. Stage migration secondary to meticulous lymph node dissection affects stage-specific survival rates. True therapeutic survival benefit of D3 resection can only be assessed in this context.
Date:
2005-03
Relation:
European Journal of Surgical Oncology. 2005 Mar;31(2):153-157.
