國家衛生研究院 NHRI:Item 3990099045/4569
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    题名: Intra-articular drug delivery systems: overcoming the shortcomings of joint disease therapy
    作者: Burt, HM;Tsallas, A;Gilchrist, S;Liang, LS
    贡献者: Center for Nanomedicine Research
    摘要: Background: Intra-articular drug delivery is very useful for treating local disease flare-ups, synovitis and pain in joints. However, the effectiveness of drugs following intra-articular administration is limited by drug delivery issues. Aim: This review addresses critical drug delivery parameters that influence the biocompatibility, tolerability and efficacy of intra-articular administrations and offers an opinion on aspects of formulation design. Methods: The relevant literature was reviewed, focusing on factors influencing tissue targeting, safety and effectiveness of particulate formulations. Results/conclusion: Therapeutic applications of novel drug delivery systems for the localized treatment of joints have lagged significantly. Future innovations in the field will require the discovery of new therapeutic agents for regional delivery, combination regimens, novel biomaterials as drug carriers and targeting carriers to specific molecules.
    日期: 2009-01
    關聯: Expert Opinion on Drug Delivery. 2009 Jan;6(1):17-26.
    Link to: http://dx.doi.org/10.1517/17425240802647259
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1742-5247&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000262926000002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=64749105978
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