國家衛生研究院 NHRI:Item 3990099045/4673

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Title:	Decline of Maternal Neutralizing Antibody Against Enterovirus Type 71 (EV71) in Young Infants in Northern Taiwan
Authors:	Luo, ST;Chiang, PS;Chao, AS;Lin, R;Lin, TY;Lee, MS
Contributors:	Vaccine Research and Development Center
Abstract:	Background: Clinical spectrum of EV71 infection ranges from mild hand-foot-mouth disease (HFMD) to severe cases with central nervous system and cardiopulmonary involvements. In 1998, Taiwan suffered a nation-wide EV71epidemic with 405 reported severe cases and 78 fatal cases.Since then, EV71 has been endemic in Taiwan and development of EV71 vaccines has become a national priority. This cohort study was designed to understand decline of maternalEV71 neutralizing antibody titers and age-speciﬁc incidence rates of EV71 infection in Taiwan, which will be crucial for designing efﬁcacy trials of EV71 vaccines. Methods: This study is a prospective longitudinal cohort study and was approved by the Institutional Review Boardsin CGMH and NHRI. Pregnant women having prenatal exams were invited to participate. Sera were collected from participating mother/baby for measuring EV71 neutralizing antibody titers in the following schedules: last trimester from mother, umbilical cord blood at birth, and children at6, 12, 24, 36, and 48 months old. Results: The recruitment started in June 2006. By January 2008, 201 longitudinal serum specimens collected from mothers, neonates, and 6-month-old babies (one mother delivered twins) have been measured with EV71 neutralizing antibody titers. The seropositive rates (percentage ofantibody titer ≥ 1:8) in mothers, neonates, and 6-month-old babies were 61%(122/201), 46%(93/202), and 0%(0/202),respectively. Geometric mean titers (95% conﬁdence inter-vals) of serum EV71 antibody in mothers and neonates were10.2 (8.7, 11.5) and 8.5 (7.4, 9.7), respectively. Conclusions: In northern Taiwan, only 46% of neonates have protective antibody against EV71 and these maternal antibody titers have declined to undetectable level (<8) by6 months of age. Historical data in the 1998 epidemic also showed that infants under 1 year old had the highest risk of severe EV71 infection. Therefore, development of EV71vaccines in Taiwan should target infants under 6 months old.
Date:	2008-12
Relation:	International Journal of Infectious Diseases. 2008 Dec;12(Suppl. 1):E299-E300.
Link to:	http://dx.doi.org/10.1016/j.ijid.2008.05.803
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1201-9712&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000263287800748
Appears in Collections:	[Min-Shi Lee] Conference Papers/Meeting Abstract

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