國家衛生研究院 NHRI:Item 3990099045/4679
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 854917      在线人数 : 867
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/4679


    题名: Novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS and IFN gamma
    其它题名: Novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS and IFNγ
    作者: Tseng, H;Wu, S;Jiaang, W;Wang, S;Lee, S
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: Three distinct isoforms of nitric oxide synthase (NOS), neural (nNOS), endothelial (eNOS), and inducible (iNOS), utilize the L-arginine andoxygen as co-substrates and convert them into L-citrulline and nitric oxide (NO). Among them, iNOS is induced to express and generate large quantity of nitric oxide upon the stimuli of endotoxins or cytokines for involving in pathological responses at the level of μM in contrast to pMfrom nNOS and eNOS. However, NO is a double-edged molecule. The improper overproduced NO by iNOS causes in acute and chronic inflammatory related diseases. Overproduction of NO by iNOS has been implicated in various pathological processes including septic shock,tissue damage following inflammation and rheumatoid arthritis. Selective inhibition of iNOS may be beneficial in various forms of shock and inflammation, where as inhibition of nNOS may protect against neuro-injury. Accordingly, selective inhibition of nNOS or iNOS versus eNOSmay provide a novel therapeutic approach to various diseases. A series of benzothiazolium compounds were identified as novel classes ofinhibitors of nitric oxide production generated by RAW264.7 cells stimulated by LPS/IFNγ. Compared to known inhibitors for nitric oxide production, herein we have identified 100 to 1000 fold more potent inhibitors with IC50 at ~50 nM to μM range compared to L-NMMA of IC5088.4uM in our system. The structure-activity relationship to elucidate the essential structural requirements has been described. In addition, most of effective compounds did not show significant cytotoxicity. The effective benzothiazolium compounds affect the iNOS protein expression and thus the nitric oxide production.
    日期: 2004-11
    關聯: Molecular Biology of the Cell. 2004 Nov;15(Suppl.S):497A.
    Link to: http://ascb.org/files/Past-AM-Meetings/2004_Abstracts.pdf
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1059-1524&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000224648802631
    显示于类别:[李秀珠] 會議論文/會議摘要
    [蔣維棠] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000224648802631.pdf102KbAdobe PDF561检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈