| Abstract: | Cryptocarya chinensis (Hance) Hemsl. (Lauraceae) is a medium-sized evergreen tree, distributed in southern China, Japan, and Taiwan [1]. Approximately 1400 species of Formosan plants have been screened for cytotoxicity, and C.chinensis was shown to be one of the active species. Pavine alkaloids and their derivatives have been extensively studied from the basic fraction of this species [2-6]. However, the neutral-CHCl3 soluble fraction of this plant has not been studied. Investigation of the neutral-CHCl3 soluble fraction of the leaves of C.chinensis has led to the isolation of additional four new 5,6-dihydroflavanone skeleton, cryptochinenone A (1), B (2), C (3) and D (4), together with ten known compounds. Among the all isolates, infectocaryone, crytocaryone, 4'-dihydroxy-2',6'-dimethoxychalcone, cryptocaryanone A and B showed cytotoxic activities (≤ 7.25 µg/mL) against MCF-7, NCI-H460 and SF-268 cell lines, respectively. The structures of these new compounds were determined through spectroscopic analyses including extensive 2D-NMR, X-ray, and CD-ORD data. This poster describes the structural elucidation of these new compounds and the cytotoxic activities. |
