國家衛生研究院 NHRI:Item 3990099045/4726
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    题名: A phase II trial of UFUR plus gemcitabine in non-small cell lung cancer patients failing previous platinum-based chemotherapy
    作者: Chen, YM;Perng, RP;Tsai, CM;Whang-Peng, J
    贡献者: National Institute of Cancer Research
    摘要: Background: Both UFUR (Tegafur/Uracil) and gemcitabine (G) are effective agents against chemo-naïve NSCLC. The effectiveness of combination of these two agents in NSCLC patients failing previous chemotherapy is unknown.Our aim was to evaluate the efficacy of oral UFUR plus G in NSCLC patients who failed previous platinum-based chemotherapy. Methods: Treatment consisted of oral UFUR 200 mg/m2/day from days 1 to 14 and G 1000 mg/m2 intravenous infusion on days 1 and 8, of every 3 weeks. Results: Between June and November 2004, 31 patients were enrolled into the study, and 22 patients went off-study during that period. The present treatment was second-line treatment in 54.5%, and third-line or higher in 45.5%. Analyses of these 22 patients showed: mean age: 66.6, median cycles received: 3.5, and objective response rates of 22.7%. Treatment-related toxicities were mild and few. Grade 3 or 4 haematological toxicities included neutropenia in 3 patients and anemia in 3 patients. No neutropenic fever occurred. Non-haematological toxicities were all less than grade 3, except for grade 3 pneumonitis in 1 patient and grade 3 fatigue in 2 patients. Median time to disease progression was 3.8 months. Conclusions: This study demonstrated that UFUR plus gemcitabine salvage chemotherapy in NSCLC patients who have failed previous platinum-based chemotherapy produces a relatively lower toxicity profile, and a better compliance and response rate than conventional salvage chemotherapy, such as docetaxel treatment, and deserves further study. Updated data will be shown at the meeting.
    日期: 2005-06
    關聯: Journal of Clinical Oncology. 2005 Jun;23(16):Abstract number 694S.
    Link to: http://meeting.ascopubs.org/cgi/content/abstract/23/16_suppl/7296
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0732-183X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000230326604412
    显示于类别:[彭汪嘉康(1996-2007)] 會議論文/會議摘要

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