國家衛生研究院 NHRI:Item 3990099045/4784
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    題名: Acellular biological tissues loaded with a novel angiogenic agent (ginsenoside Rg1) as a tissue-engineering extracellular matrix
    其他題名: Transactions - 7th World Biomaterials Congress
    作者: Liang, HC;Huang, YC;Chen, CT;Chang, Y;Lai, PH;Sung, HW
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: The study was to in vitro investigate the effects of ginsenoside Rg1, a natural compound extracted from Panax ginseng, on the proliferation of human umbilical vein endothelial cells (HUVEC). Basic fibroblast growth factor (bFGF) was used as a control. Additionally, angiogenesis and tissue regeneration in a genipin-fixed acellular bovine pericardium (ECM) loaded with Rg1 were investigated subcutaneously in a rat model. The ECMs without drug loading or loaded with bFGF were used as controls. The in vitro results revealed that both bFGF and Rg1 significantly induced HUVEC proliferation. The in vivo results obtained at 1-week postoperatively showed that angiogenesis in the ECM was significantly enhanced by bFGF and Rg1. These results indicated that ginsenoside Rg1 may be a new class of angiogenic agent and may be loaded in the ECM for tissue regeneration. Further in vivo study is still underway.
    日期: 2004
    關聯: Transactions - 7th World Biomaterials Congress. 2004:1725.
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=13844299573
    顯示於類別:[陳炯東] 會議論文/會議摘要

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