國家衛生研究院 NHRI:Item 3990099045/4790
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    题名: Homologous RBC-derived vesicles as ultrasmall carriers of iron oxide for magnetic resonance imaging of stem cells
    作者: Chang, M;Hsiao, JK;Yao, M;Chien, LY;Hsu, SC;Ko, BS;Chen, ST;Liu, HM;Chen, YC;Yang, CS;Huang, DM
    贡献者: Center for Nanomedicine Research
    摘要: Ultrasmall superparamagnetic iron oxide ( USPIO) particles are very useful for cellular magnetic resonance imaging (MRI), which plays a key role in developing successful stem cell therapies. However, their low intracellular labeling efficiency, and biosafety concerns associated with their use, have limited their potential usage. In this study we develop a novel system composed of RBC-derived vesicles (RDVs) for efficient delivery of USPIO particles into human bone marrow mesenchymal stem cells (MSCs) for cellular MRI in vitro and in vivo. RDVs are highly biosafe to their autologous MSCs as manifested by cell viability, differentiation, and gene microarray assays. The data demonstrate the potential of RDVs as intracellular delivery vehicles for biomedical applications.
    日期: 2010-06-11
    關聯: Nanotechnology. 2010 Jun;21(23):Article Number 235103.
    Link to: http://dx.doi.org/10.1088/0957-4484/21/23/235103
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0957-4484&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000277746900005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955888026
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    [黃東明] 期刊論文

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