國家衛生研究院 NHRI:Item 3990099045/4797

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Title:	Gold-nanoparticle enhanced in-situ immunosensor based on fiber-optical Fabry-Perot interferometry
Other Titles:	2005 5th IEEE Conference on Nanotechnology
Authors:	Tseng, YT;Wu, YC;Yang, CS;Wang, MC;Tseng, FG
Contributors:	Center for Nanomedicine Research
Abstract:	This paper proposes a novel method employing gold-nanoparticle to enhance optic fiber Fabry-Perot (F-P) interferometry signal and applyed to immunoassay of rabbit IgG and anti-rabbit IgG. In the sensor preparation, cysteine molecules were immobilized on the sensor surface to allow attachment of gold-nanoparticles. Experiment results show that the spectrum shift can be improved by one order of magnitude as employing 40nm nanoparticles compared to the traditional detection ways by Febry-Perot interferometry. The minimum detectable concentration of 10<sup>7</sup> particles/μl was reached. Furthermore, the fiber sensor system was applied to the detection of immuno-reaction of rabbit-IgG and anti-rabbit IgG. The whole immuno sensing process including antibody binding and surface regeneration by elution took about 9 minutes, 3 times faster than the traditional way by micro dialysis. c2005 IEEE.
Date:	2005-07
Relation:	2005 5th IEEE Conference on Nanotechnology. 2005 Jul;2:117-120(Article number 1500665).
Link to:	http://dx.doi.org/10.1109/NANO.2005.1500665
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33746917553
Appears in Collections:	[Chung-Shi Yang] Conference Papers/Meeting Abstract

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