國家衛生研究院 NHRI:Item 3990099045/4807

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Title:	Characterization of yeasts colonizing in healthy individuals
Authors:	Yang, YL;Leaw, SN;Wang, AH;Chen, HT;Cheng, WT;Lo, HJ
Contributors:	Division of Infectious Diseases
Abstract:	Opportunistic yeast pathogens may switch from harmless commensal to pathogenic relationships with the host under different conditions. They usually cause superficial infections, but may be the agents of more significant infections in immunocompromised patients. To investigate yeast colonization in the oral cavities of clinically healthy individuals, we collected oral swabs from 323 students and staff at the National Health Research Institutes, Taiwan. A total of 49 (15.2%) volunteers were colonized by low levels of yeasts and of these, only 3 (6.1%) were co-colonized by more than one species. Among the 52 isolates, comprising seven fungal genera and 13 species, Candida albicans (57.7%) was the dominant species, followed by Candida parapsilosis (15.4%). There was only one isolate of C. parapsilosis that showed, in vitro, a high (2 mug/ml) minimum inhibitory concentration (MIC) to amphotericin B. There were six (11.5%) isolates with fluconazole MICs >/= 64 mug/ml and all of them were non-Candida species. With the exception of Cryptococcus albidus, the remaining five isolates had voriconazole MICs >/= 4 mug/ml. In addition, there was one C. albicans isolate with relatively high fluconazole (32 mug/ml) and voriconazole (4 mug/ml) MICs.
Date:	2011-01
Relation:	Medical Mycology. 2011 Jan;49(1):103-106.
Link to:	http://informahealthcare.com/doi/abs/10.3109/13693786.2010.487076
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1369-3786&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000285247000016
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78650404406
Appears in Collections:	[Hsiu-Jung Lo] Periodical Articles

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