國家衛生研究院 NHRI:Item 3990099045/4809
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    题名: Strain differences in the chronic mild stress animal model of depression
    作者: Wu, HH;Wang, S
    贡献者: Division of Mental Health and Addiction Medicine
    摘要: Hypothalamic-pituitary-adrenal (HPA) axis dysfunction has been implicated in depression pathology. In the present study, we used a chronic mild stress (CMS) animal model of depression to examine the responses of three strains of rats that have different HPA axis responsiveness; and whether the behavioral changes observed are correlated with changes in hippocampal cell proliferation and survival. In addition, in most of the CMS experiments the rats are kept in singly housed condition. Since rats are social animals we also examined whether prolonged single housing condition affects the behavior of the rats. The results showed that rats with a hyperactive HPA axis, the inbred Fischer (F344) rat, were the most responsive to CMS. The inbred Lewis (LEW) rat, which has a hypoactive HPA axis, did not show anhedonia after CMS treatment but showed other signs of distress. The responses of the outbred Sprague-Dawley (SD) rats were variable; this strain was very sensitive to the single housing condition. Prolonged single housing condition itself could induce helplessness behavior in the rats. The results from hippocampal cell proliferation of the three strains indicated that cell proliferation was not related to anhedonia induced by CMS. We conclude that F344 rat is the strain most sensitive to CMS treatment and is probably the stain of choice for CMS experiments.
    日期: 2010-11-12
    關聯: Behavioural Brain Research. 2010 Nov 12;213(1):94-102.
    Link to: http://dx.doi.org/10.1016/j.bbr.2010.04.041
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0166-4328&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000279501100013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77953361630
    显示于类别:[王先逸(2005-2010)] 期刊論文

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